About Me

I am a computational human geneticist interested in the complex relationship between genotype, phenotype, and natural selection. My training and experience sit at the interface of multiple fields: theoretical genetics, molecular biology, bioinformatics and machine learning, medical genetics, biomedical informatics, protein physics, and more. My favorite projects are those that break new ground by reaching across multiple of these disciplines. My goal is to build innovative computational models and useful software tools that will enable new advances in the clinic and new insights into biological causation.

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RESEARCH INTERESTS

AI Phenotyping for Rare Disease

I develop methods to extract signatures of rare disease from electronic health records using AI.

Genome Interpretation

I develop methods to predict and characterize the effects of genetic variants on human disease and the complex ways these effects can combine.

Polygenic Causation and Pleiotropy

I investigate the causal relationships between complex traits and diseases, and develop methods to explore the effects of genetic variation on these relationships.

EDUCATION

2015-2020 Postdoctoral Fellowship

Icahn School of Medicine at Mount Sinai

I did a joint postdoc under Ron Do and Eric Schadt in the Charles Bronfman Institute for Personalized Medicine and the Department of Genetics and Genomic Sciences. I worked on projects in complex trait genetics, computational systems biology, and AI phenotyping in electronic health records.

2008-2015 Ph.D in Biophysics

Harvard Graduate School of Arts and Sciences

I did my Ph.D. with Shamil Sunyaev in the Division of Genetics at Brigham and Women's Hospital. I studied the evolution of rare protein coding variation and developed methods that used machine learning to predict the effects of this variation on human health.

Systems Biology

I analyze state-of-the-art multi-omics data to learn about the biology and genetics underlying complex biological phenomena.

2002-2006 B.A. cum laude

Yale College

I majored in Physics and Philosophy at Yale.